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Cardiovascular diseases (CVD) represent a major health problem in adult population worldwide. Together with conventional risk factors, gamma-glutamyl transferase (GGT) is involved in the pathogenesis of CVD. The purpose of this review is to provide informations about GGT synthesis, physiological roles and the involvement in the atherosclerotic plaque formation. The results of the most recent clinical studies performed to find an association between GGT serum activity and patients with hypertension and coronary artery disease (CAD) are presented.