Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh
oleh: Siti Nadiah Abdul Halim, Noraini Kasim, Hazrina Hazni, Fasihuddin bin Ahmad, Jamaludin bin Mohamad, Kok Hoong Leong, Khalit bin Mohamad, Vicky Bihud, Rosalind Pei Theng Kim, Khalijah Awang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2012-12-01 |
Deskripsi
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.