Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets
oleh: L. Mathur, B. Szalai, N. H. Du, R. Utharala, M. Ballinger, J. J. M. Landry, M. Ryckelynck, V. Benes, J. Saez-Rodriguez, C. A. Merten
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Current screens to assess tumour drug resistance require a large amount of material, normally not available from patients. Here the authors report CombiSeq, a scalable microfluidic workflow to screen hundreds of drug combinations in picoliter-size droplets using transcriptome changes as a readout.