Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis of meso-cyclic anhydrides
oleh: Lingjun Xu, Shuwen Han, Linjie Yan, Haifeng Wang, Haihui Peng, Fener Chen
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2018-01-01 |
Deskripsi
A family of novel chloramphenicol base-amide organocatalysts possessing a NH functionality at C-1 position as monodentate hydrogen bond donor were developed and evaluated for enantioselective organocatalytic alcoholysis of meso-cyclic anhydrides. These structural diversified organocatalysts were found to induce high enantioselectivity in alcoholysis of anhydrides and was successfully applied to the asymmetric synthesis of (S)-GABOB.