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Changes in haematological parameters in dogs with cystic endometrial hyperplasia-pyometra (CEH-Pyometra)was assessed. Haemoglobin (Hb), volume of packed red cells (VPRC), total erythrocyte count (TEC) and lymphocyte count were found to be decreased while the total leucocyte count (TLC) and neutrophil per cent was increased in dogs withCEH Pyometra. Erythrocytic indices like mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) did not show any significant changes in these dogs and were in the normal range. Predominant leucocytosis(mean 25.56±2.24 ×103 /mm3 )with neutrophilia(mean84.83±1.22 %),lymphopenia (mean 12.33±0.95 %) andnormocytic normochromic anaemiawere the most common findings in bitcheswith CEHPyometra