A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China

oleh: Hong-xing Li, Mei Dong, Xiao-xiao Peng, Yi-zhe Liu, Han Wang, Chao Li, Yi-yi Du, Kai Zhang, Qiang Zong

Format: Article
Diterbitkan: Frontiers Media S.A. 2023-02-01

Deskripsi

BackgroundAlthough Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (PRKN) mutations.CaseIn this study, we report the case of a 30-year-old Chinese woman who was affected by PRKN-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.ConclusionThis case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of PRKN-associated YOPD.