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Successful management with urgent haploidentical‐peripheral blood stem cell transplantation for a patient with severe aplastic anaemia who developed disseminated fungal infection following immunosuppressive therapy
oleh: Norihito Ikenobe, Kentaro Fujimori, Yoshihiro Gocho, Shota Myojin, Masaki Yamada, Kenichi Imadome, Mikiko Miyasaka, Osamu Miyazaki, Akihiro Yoneda, Shotaro Matsumoto, Satoshi Nakagawa, Takao Deguchi, Akihiro Iguchi, Daisuke Tomizawa, Chikara Ogimi, Kimikazu Matsumoto, Hirotoshi Sakaguchi
Format: | Article |
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Diterbitkan: | Wiley 2024-10-01 |
Deskripsi
Abstract Urgent haploidentical haematopoietic cell transplantation may be considered in cases of severe aplastic anaemia (SAA) without a human leukocyte antigen‐matched donor and suffering from severe infection. However, deciding on allogeneic transplantation in the setting of active systemic infection is challenging due to poor outcomes. This report presents a case of disseminated Magnusiomyces capitatus infection in a 5‐year‐old male who underwent immunosuppressive therapy for hepatitis‐associated SAA. To address the critical situation, granulocyte transfusion was promptly administered from the patient's mother, followed by unmanipulated haploidentical peripheral blood stem cell transplantation from the patient's father with posttransplant cyclophosphamide, ultimately resulting in successful rescue.