Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination
oleh: Ved P. Sharma, Binwu Tang, Yarong Wang, Camille L. Duran, George S. Karagiannis, Emily A. Xue, David Entenberg, Lucia Borriello, Anouchka Coste, Robert J. Eddy, Gina Kim, Xianjun Ye, Joan G. Jones, Eli Grunblatt, Nathan Agi, Sweta Roy, Gargi Bandyopadhyaya, Esther Adler, Chinmay R. Surve, Dominic Esposito, Sumanta Goswami, Jeffrey E. Segall, Wenjun Guo, John S. Condeelis, Lalage M. Wakefield, Maja H. Oktay
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastatic tumors in breast cancer patients.