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Diabetes Mellitus is a metabolic disorder with deleterious effect on the physiological functioning of body systems. The predisposition of body organs and tissues to infections, nervous and circulatory dysfunction brands this disease with a wide spectrum of clinical manifestations. The present scenario in the management of patients with diabetes has shifted from symptom-specific treatment to a holistic approach in the overall treatment of soft and hard tissue pathologies presented by the disease. A deeper comprehension of the pathogenesis of diabetic complications, both general and local, can serve as an ally in rendering a “tailored” treatment which not only alleviates the symptoms but treats the underlying cause. This article addresses the generalised effect of hyperglycaemia and its insidious but progressive effect on the dental pulp.