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Background: this study aimed to evaluate the effect of eight weeks of moderate intensity aerobic exercise with Resveratrol supplementation on vascular adhesion molecules (VCAM-1 and ICAM-1) and tumor necrosis factor alpha (TNF-α) in the heart tissue of male rats with type 2 diabetes. Materials and Methods: The present study was experimental. Statistical samples included 2-month-old male rats weighing 270-230 g. Rats were divided into 5 groups of 6 after familiarity with training protocols; Healthy control, diabetic control (Streptozocin), diabetes supplement, diabetic exercise and exercise + diabetic supplement. 9 mg / kg Resveratrol was given daily to each rat. The study lasted eight weeks. Results: The amount of TNF-α in the exercise + diabetic supplement group was significantly reduced compared to the diabetic control group (P=0.001), and in the exercise + diabetic supplement group was significantly reduced compared to the diabetic exercise group (P= 0.001). The levels of ICAM-1 and VCAM-1 in the exercise + diabetic supplement group were significantly reduced compared to the diabetic control group (P=0.001). The level of ICAM-1 in the diabetic exercise + diabetic supplement group was significantly reduced compared to the diabetic supplement group and the diabetic exercise group, and the level of VCAM-1 in the exercise + diabetic supplement group was significantly reduced compared to the diabetic supplement group (P=0.001). Conclusion: The results showed that diabetes increases TNF-α, ICAM-1 and VCAM-1, but exercise and Resveratrol reduce it. Also, a combination of exercise and Resveratrol can lead to better effects.