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Two undescribed cytochalasins, emeriglobosins A (<b>1</b>) and B (<b>2</b>), together with nine previously reported analogues (<b>3</b>–<b>11</b>) and two known tetramic acid derivatives (<b>12</b>, <b>13</b>) were isolated from the solid culture of <i>Emericellopsis</i> sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, <b>8</b> showed potent AChE inhibitory activity, with an IC₅₀ value of 1.31 μM, and <b>5</b> showed significant cytotoxicity against PC-3 cells, with an IC₅₀ value of 2.32 μM.