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Since the beginning of humanity, many sectors have produced different chemicals. These chemicals are the main causes of environmental pollution and have become a global problem with irreversible effects in terms of health. Because of this, countries have set a target of “a pollution-free planet”. We need to determine target-specific strategies to both eliminate pollution and protect health. To date, traditional methods of monitoring in receiving aquatic environments have been used; however, they do not provide information on toxic levels of pollutants. For this reason, researchers have focused on “bio-indicator” or “bio-monitor” organisms. Since these organisms are in equilibrium with the aquatic environment, they can also be considered an integrated sampling tool and may indicate potential contamination. <i>Danio rerio</i> (zebrafish) is considered a promising model organism for single health studies in terms of its biological structure. This review aims to present <i>Danio rerio</i>’s characteristics, susceptibility to environmental pollutants, and risks associated with pollutants in the aquatic environment.