Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression
oleh: Aleksandr Talishinsky, Jonathan Downar, Petra E. Vértes, Jakob Seidlitz, Katharine Dunlop, Charles J. Lynch, Heather Whalley, Andrew McIntosh, Fidel Vila-Rodriguez, Zafiris J. Daskalakis, Daniel M. Blumberger, Conor Liston
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
The neural substrates of depression may differ by sex. Here the authors show that depression is associated with distinct brain connectivity changes in men and in women that are explained by sex-specific transcriptomic signatures involving genes previously implicated in synapse function, immune signalling, and depression risk.