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Biopolymer-based dressings have great potential for wound healing applications. This study was focused on fabrication of pectin-sodium alginate dressings and further coating then with Croton oblongifolius (CO) crude extract. The resulting dressings were then characterized for their physiochemical, blood clotting and biocompatible properties. SEM studies confirmed presence of CO extract on the dressing. Moreover, physical characterization revealed a porosity of about 90%, which supported the absorption of ~5.2 g of wound exudates and exhibited moisture vapor transmission rate of about 3771 g/m2/24 h, both of which are vital properties for efficient wound healing. The prepared herbal dressing exhibited better blood clotting efficiency and resulted in thrombin generation of 41.36 ng/mL, as compared to the control dressing (without CO extracts) that generated only 2.1 ng/mL of Thrombin-Antithrombin complex (TAT). Further, it showed limited toxicity towards primary human dermal fibroblasts (HDF) from human skin. In addition, the herbal dressing displayed a zone of inhibition of 8 mm for E.coli, which confirmed its antimicrobial activity.