T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells
oleh: Hye-Ran Kim, YeVin Mun, Kyung-Sik Lee, Yoo-Jin Park, Jeong-Su Park, Jin-Hwa Park, Bu-Nam Jeon, Chang-Hyun Kim, Youngsoo Jun, Young-Min Hyun, Minsoo Kim, Sang-Myeong Lee, Chul-Seung Park, Sin-Hyeog Im, Chang-Duk Jun
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-09-01 |
Deskripsi
Microvilli can participate in adhesion or migration of T cells, but whether they are involved in function regulation is unclear. Here the authors show that T cell microvilli form budding vesicles containing T cell signalling components for deposition onto antigen presenting cells (APC) and modulation of APC functions.