Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
oleh: Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-02-01 |
Deskripsi
Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cytotoxic CD8+T-cell- and TNFα-dependent manner.