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Background and Aim: Stroke is one of the most important factors of mortality and disability in the world. Free radicals are produced following ischemic stroke and they play a central role in breaking the blood-brain barrier and&nbsp; causing brain edema formation. The aim of the current study was to evaluate the effect of hydro- alcoholic extract of Origanum vulgare on brain edema and neurologic deficit in a rat stroke model. Materials and Methods: In thisexperimental study, 35 male Wistar rats were randomly divided into 5 equal groups.&nbsp; The first&nbsp; two groups (control and Sham)) received distilled water, while three treatment groups received oral Origanum vulgare extract for 30days (50,75and 100 mg/kgdaily, respectively).&nbsp; Two hours after the last dose of Origanum vulgare extract,each main group underwent&nbsp; a 60 min middle cerebral artery occlusion.&nbsp; Then, the assessment of blood brain edema, and neurologic deficits analysis were done . Brain edema (brain water content) was analyzed by One-Way ANOVA using LSD method and neurologic deficits analysis by means of Mann-Whitney U, and P<0.05 was taken as the significant level. Results: Origanum vulgare extract reduced brain edema in the experimental groups of 50 (82.49&plusmn;0.47), 75 (80.89&plusmn;0.63) and 100 mg/kg/day (80.80&plusmn;0.66) compared to the control group (84.46&plusmn;0.67). The neurologic deficit scores in the experimental groups of 75and 100mg/kg/day, compared with control group, but neurologic deficit scores did not affect the group receiving the dose 50 mg/kg. Conclusion: &nbsp;The obtained data indicate that Origanum vulgar extract via reduction of brain edema and neurologic deficits scorescan have a protective effect on the stroke model.