Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response
oleh: Dong-Jing Cai, Zi-Yu Zhang, Yue Bu, Li Li, Yue-Zhen Deng, Lun-Quan Sun, Cheng-Ping Hu, Min Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Publishing Group 2022-06-01 |
Deskripsi
In the Wnt pathway, phosphorylation of GSK3β(S9) is very important to stabilize β-catenin complex, ASNS can upregulate phosphorylation of AKT on Ser473, then promote GSK3β phosphorylation on Ser9 to stabilize β-catenin complex. When Wnt pathway is activated, ASNS elevates p-DRP1(637) and decreases p-DRP1(616) to suppress mitochondrial fission.