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This paper considers the possibilities of increasing radiation resistance to helium swelling of beryllium oxide ceramics due to preliminary irradiation with heavy ions. Interest in this topic is due to the possibility of using these ceramics as materials for inert matrices of nuclear fuel and structural materials reflectors of high-temperature reactors. The samples studied were irradiated in two stages, namely irradiation with heavy Ar⁸⁺, Kr¹⁵⁺, and Xe²²⁺ ions with a fluence of 10¹² ion/cm² and subsequent irradiation with He²⁺ ions with a fluence of 5x10¹⁷ ion/cm². The main parameters used to compare and determine radiation modification efficiency were the crystal-structure swelling degree, a decrease in the hardness, and wear resistance of ceramics after irradiation with He²⁺ ions. During the studies carried out, it was found that preliminary irradiation with heavy Ar⁸⁺, Kr¹⁵⁺, and Xe²²⁺ ions leads to a significant increase in radiation swelling resistance, as well as to an increase in crack resistance and wear resistance.