Adult form of Langerhans cell histiocytosis with pulmonary and hepatic involvement mimicking malignancy in a patient with chronic hepatitis C infection
oleh: Barbara Moullet, MD, Mirjam Kolev, MD, Lukas Ebner, MD, Rupert Langer, MD, Christoph Gräni, MD, PhD, Verena Obmann, MD, Martin Maurer, MD, Nasser Semmo, MD, PhD, Andreas Christe, MD, Adrian Thomas Huber, MD, PhD
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-02-01 |
Deskripsi
Langerhans cell histiocytosis (LCH) is a myeloid neoplasm with inflammatory properties. There are few published reports of adult LCH with liver involvement, which is still poorly understood, but shows high morbidity and mortality. We report a case of a 37-year-old woman suffering from hepatitis C showing a LCH affecting the lung as well as the liver. Consistent with histology, we found an early stage of a proliferative/granulomatous phase of hepatobiliary LCH, whereas pulmonary findings showed a nodular stage of adult pulmonary LCH. Although hepatocellular carcinoma is a common malignancy in patients suffering from hepatitis C, it is crucial to keep in mind differential diagnosis for newly appearing liver lesions.