Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
oleh: A. Taylor Bright, Thamer Alenazi, Sandra Shokoples, Joel Tarning, Giacomo M. Paganotti, Nicholas J. White, Stanley Houston, Elizabeth A. Winzeler, Stephanie K. Yanow
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2013-05-01 |
Deskripsi
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.