Synthesis of Six-Membered <i>N</i>-Heterocyclic Carbene Precursors Based on Camphor
oleh: Jan Šegina, Luka Ciber, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2023-12-01 |
Deskripsi
The <i>endo</i>- and <i>exo</i>-<i>N</i>-heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1<i>S</i>)-(+)-ketopinic acid. The obtained <i>N</i>-heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.