Cancer co-opts differentiation of B-cell precursors into macrophage-like cells
oleh: Chen Chen, Bongsoo Park, Emeline Ragonnaud, Monica Bodogai, Xin Wang, Le Zong, Jung-Min Lee, Isabel Beerman, Arya Biragyn
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
The tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to cancer progression and metastasis via disabling local T cell response.