BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
oleh: Weiran Feng, Maria Jasin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
BRCA2 mutations promote tumour formation while also paradoxically causing cell lethality. Here the authors generate conditional BRCA2 loss in a non-transformed human mammary cell line and see increased replication stress due to under-replication of DNA.