RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells
oleh: Dimitri Van Simaeys, Adriana De La Fuente, Serena Zilio, Alessia Zoso, Victoria Kuznetsova, Oscar Alcazar, Peter Buchwald, Andrea Grilli, Jimmy Caroli, Silvio Bicciato, Paolo Serafini
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Development of probes specific for human β-cells could aid in delivery of therapeutics and monitoring β-cells mass during diabetes progression or islet transplantation. Here the authors identify two RNA aptamers specific for β-cells that allow efficient transfection of human islets and β-cell quantification of human islet grafts in immunodeficient mice.