Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
oleh: Maria E. Monberg, Heather Geiger, Jaewon J. Lee, Roshan Sharma, Alexander Semaan, Vincent Bernard, Justin Wong, Fang Wang, Shaoheng Liang, Daniel B. Swartzlander, Bret M. Stephens, Matthew H. G. Katz, Ken Chen, Nicolas Robine, Paola A. Guerrero, Anirban Maitra
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
It is unclear if the molecular profiles of pancreatic ductal adenocarcinoma (PDAC) preclinical models remain stable during propagation. Here, the authors characterise clonal evolution throughout propagation in PDAC cell lines and a patient-derived organoid using single-cell genomics, transcriptomics and epigenomics.