Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni
oleh: Kyungjin Min, Doo Ri An, Hye-Jin Yoon, Neha Rana, Ji Su Park, Jinshil Kim, Mijoon Lee, Dusan Hesek, Sangryeol Ryu, B. Moon Kim, Shahriar Mobashery, Se Won Suh, Hyung Ho Lee
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Peptidoglycans (PG) define bacterial cell shapes. Here, the authors provide mechanistic insights into the peptidoglycan peptidase 3 (Pgp3) from the spiral shaped human pathogen Campylobacter jejuni by determining its crystal structure alone and in complex with synthetic cell-wall PG derivatives, and they further show that the enzyme has both d,d-endopeptidase and d,d-carboxypeptidase activities