Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy
oleh: Zi-Yue Zhao, Zi-Yue Zhao, Zhuo-Yuan Chen, Zhuo-Yuan Chen, Bin Yu, Bin Yu, Bo Xiao, Bo Xiao, Li-Yan Liu, Li-Yan Liu, Yu Xia, Yu Xia, Ao-Yu Li, Ao-Yu Li, Ping-Xiao Wang, Ping-Xiao Wang, Cheng Xiang, Cheng Xiang, Chao Liu, Chao Liu, Hui-Qin Yang, Hui-Qin Yang, Hui-Qin Yang, Hui Li, Hui Li, Tao Xiao, Tao Xiao
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2022-07-01 |
Deskripsi
Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B/C and gene clusters A/B/C. Then, a close relationship between ICI and gene clusters was established. We found that the features of these clusters were consistent with the characteristics of immune-inflamed tumors (cluster C), immune-desert tumors (cluster B), and immune-excluded tumors (cluster A). Moreover, cluster C was sensitive to immunotherapy. Finally, an independent ICI score was established to predict the therapeutic effect, which has prospects for application in guiding immunotherapy during clinical practice.