Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter
oleh: Tim Schulte, Antonio Chaves-Sanjuan, Giulia Mazzini, Valentina Speranzini, Francesca Lavatelli, Filippo Ferri, Carlo Palizzotto, Maria Mazza, Paolo Milani, Mario Nuvolone, Anne-Cathrine Vogt, Monique Vogel, Giovanni Palladini, Giampaolo Merlini, Martino Bolognesi, Silvia Ferro, Eric Zini, Stefano Ricagno
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Here, the authors report the cryoEM structure of AA amyloid from a cat shelter with extreme disease prevalence and reveal the feline-specific sequence insert in the fibril core. The sequence is 99% identical to AA amyloid from cheetah with reported prion-like transmission in zoos.