Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA
oleh: Yuan Tian, Mariana Babor, Jerome Lane, Veronique Schulten, Veena S. Patil, Grégory Seumois, Sandy L. Rosales, Zheng Fu, Gaelle Picarda, Julie Burel, Jose Zapardiel-Gonzalo, Rashika N. Tennekoon, Aruna D. De Silva, Sunil Premawansa, Gayani Premawansa, Ananda Wijewickrama, Jason A. Greenbaum, Pandurangan Vijayanand, Daniela Weiskopf, Alessandro Sette, Bjoern Peters
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Memory T cells are essential for combating recurring infection by promoting prompt and effective immune responses. Here the authors show, via system biology approaches, that human CD4 memory T cells contains a CD45RA-rexpressing pool that can be further subsetted by the expression of GPR56 for distinct functionalities.