GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway
oleh: Anran Xu, Yuanyuan Fan, Song Liu, Lianbing Sheng, Yanyan Sun, Huijun Yang
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2022-12-01 |
Deskripsi
Highlights 1. GIMAP7 is upregulated in ovary granulosa cells of PCOS rat; 2. GIMAP7 shRNA relieves the symptoms of PCOS rats; 3. GIMAP7 shRNA inhibits the apoptosis and oxidative stress of KGN cells; 4. GIMAP7 inhibits sonic hedgehog signalling pathway in KGN cells.