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Sericulture in India provides employment to rural youth and women engaged in its various activities. During raw silk processing, a compound known as sericin is released into the environment which causes water pollution if not recovered from discharged water. A study was carried out to utilize the waste product i.e. sericin for the treatment of cotton fabric and see its effect on the properties of fabric. Treatment was given using cross linking agent and catalyst, fabric was later dyed with natural dye manjistha. The treated fabric was tested for crease recovery, wettability, air permeability and UV protection properties. The results revealed that application of silk protein enhances properties of cotton fabric.