N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA

oleh: Xiang Zhang, Huilong Yin, Xiaofang Zhang, Xunliang Jiang, Yongkang Liu, Haolin Zhang, Yingran Peng, Da Li, Yanping Yu, Jinbao Zhang, Shuli Cheng, Angang Yang, Rui Zhang

Format: Article
Diterbitkan: Nature Portfolio 2022-11-01

Deskripsi

Here the authors find that the mRNA of GYS2, the liver-specific glycogen synthase, is a substrate of METTL3 and IGF2BP2 and that m6A-mediated regulation of Gys2 mRNA is critical for the maintenance of liver glycogenesis in mammals during growth, such as mice and rats.