Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

oleh: Divija Deshpande, Nitin Agarwal, Thomas Fleming, Claire Gaveriaux-Ruff, Christoph S. N. Klose, Anke Tappe-Theodor, Rohini Kuner, Peter Nawroth

Format: Article
Diterbitkan: Nature Portfolio 2021-01-01

Deskripsi

Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.