Coconut Shell Liquid Smoke Promotes Burn Wound Healing
oleh: Vita Murniati Tarawan MD, PhD, Kemala Isnainiasih Mantilidewi MD, PhD, Ika Miqra Dhini MD, MHS, Putri Teesa Radhiyanti MD, MHS, Endang Sutedja MD, PhD
| Format: | Article |
|---|---|
| Diterbitkan: | SAGE Publishing 2017-07-01 |
Deskripsi
The aim of this study was to evaluate burn wound healing activity of coconut shell liquid smoke (CS-LS) in a burn wound animal model. Burn wound–induced mice were treated with CS-LS (CS-LS group), povidone iodine 10% (povidone group), or NaCl 0.9% (NaCl group). Application of CS-LS promoted wound contraction compared to that of the povidone and NaCl groups ( P < .05). This study showed a positive correlation between the number of fibroblasts and wound contraction. The number of fibroblasts was highest in the CS-LS group, compared to that of the povidone and NaCl groups ( P < .05). In conclusion, CS-LS promotes burn wound healing by one possible mechanism, by increasing the number of fibroblasts. The results indicate that further experimental trials are needed to develop CS-LS as an alternative topical drug for burn wound healing.