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Evaluation of the Antidiabetic and Antihyperlipidemic Activity of <i>Spondias purpurea</i> Seeds in a Diabetic Zebrafish Model
oleh: Alethia Muñiz-Ramirez, Abraham Heriberto Garcia-Campoy, Rosa Martha Pérez Gutiérrez, Efrén Venancio Garcia Báez, José María Mota Flores
Format: | Article |
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Diterbitkan: | MDPI AG 2021-07-01 |
Deskripsi
Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy; therefore, new natural alternatives are being sought to control the disease. In this work, we evaluate the antidiabetic effect of <i>Spondias purpurea</i> seed methanol extract (CSM) in vitro and in a glucose-induced diabetic zebrafish model. CSM is capable of lowering blood glucose and cholesterol levels, as well as forming advanced glycation end-products, while not presenting toxic effects at the concentrations evaluated. These data show that CSM has a promising antidiabetic effect and may be useful in reducing some of the pathologies associated with diabetes mellitus.