Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
oleh: Erik Elias, Arman Ardalan, Markus Lindberg, Susanne E. Reinsbach, Andreas Muth, Ola Nilsson, Yvonne Arvidsson, Erik Larsson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse multifocal SI-NET tumours with whole-genome sequencing, revealing the landscape of genomic alterations and frequent polyclonal origins.