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The title compound, 2-methoxy-5-{4-oxo-2-[(<em>E</em>)-2-(4-sulfamoylphenyl) ethenyl-3, 4-dihydroquinazolin-3-yl] benzene-1-sulfonamide <strong>2</strong> has been synthesized by the reaction of 3-(4-methoxyphenyl)-2-styryl-4(3<em>H</em>)-quinazolinone <strong>1</strong> with an excess of chlorosulfonic acid, followed by amidation of the sulfonyl chloride product with ammonia gas. The structure of the synthesized compound was confirmed on the basis of IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and mass spectral data.