Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
oleh: Katarina Savić Vujović, Sonja Vučković, Radan Stojanović, Nevena Divac, Branislava Medić, Dragana Srebro, Marko Kadija, Milica Prostran
| Format: | Article |
|---|---|
| Diterbitkan: | Sciendo 2018-03-01 |
Deskripsi
Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist. Magnesium is an endogenous non-competitive NMDA antagonist that causes anion channel blockade in a dose-dependent manner. It has been established that ketamine and magnesium interact synergistically in the tail-immersion test in rats.