Find in Library

Gestational diabetes mellitus (GDM) is a metabolic disturbance in pregnancy, traditionally defined as glucose intolerance with onset or first recognition during pregnancy with the outcome of perinatal and offspring complications. The common diagnostic criteria of oral glucose tolerance test in the second or third trimester of pregnant women help to detect the later complications of GDM. Early detection is lacking and highly essential to prevent GDM. We aim to assess the role of glycated hemoglobin and hematocrit for the early screening of GDM.We recruited 403 study participants, collected demographic profiles and medical histories. The levels of glucose, hemoglobin (Hb), glycated hemoglobin (HbA1c), hematocrit (PCV), and thyroid-stimulating hormone (TSH) were measured in the serum samples of study participants. The ROC curve was plotted, cut-off, an area under the curve, specificity, and sensitivity of glycated hemoglobin and hematocrit was calculated using statistical software.In our study, we observed there is a significant difference in the levels of Hb, PCV, and HbA1c between non-GDM and GDM patients. We found the prevalence of GDM 20.88% in our study population. An HbA1c cut of at 5.25% and PCV 34.5%, the sensitivity and specificity of HbA1c as 64.4% and 36.1%, the sensitivity and specificity of PCV as 58.6% and 43.1% respectively. The combined HbA1c & PCV screening results had shown the sensitivity of 36.8% and specificity of 85.4% using the ROC curve.In conclusion, the cut-off values, specificity, and sensitivity of HbA1c and Haematocrit and its combined calculation in the first trimester of pregnant women will be more specific and sensitive early screening tools for GDM.