A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
oleh: Sebastian G. Wicha, Chunli Chen, Oskar Clewe, Ulrika S. H. Simonsson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-12-01 |
Deskripsi
Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.