HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
oleh: Florent Percher, Céline Curis, Eléonore Pérès, Maria Artesi, Nicolas Rosewick, Patricia Jeannin, Antoine Gessain, Olivier Gout, Renaud Mahieux, Pierre-Emmanuel Ceccaldi, Anne Van den Broeke, Madeleine Duc Dodon, Philippe V. Afonso
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin vitro, and increases the number of infected clones in mice.