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Introduction: More than half of women complaining of breast symptoms are affected by benign breast disorders (BBD). Thyroid dysfunction has been implicated as the etiology. Therefore, we conducted a study to assess the association between BBD and hypothyroidism.Methods: In this case-control study, 226 women with BBD without a history of thyroid disorders were recruited consecutively as the case group. Controls included 206 healthy women without breast disease. Blood samples were taken, and the levels of free thyroxin, tri-iodothyronine, thyroid stimulating hormone, prolactin, and anti-thyroid peroxidase antibody were measured.Results: Hypothyroidism was insignificantly more frequent in the case (5.8%) than in the control group (5.3%), as well as in cases of fibrocystic changes (7.9%) in comparison with mastalgia (1.4%) and nipple discharge (2.6%) in the BBD subgroups (p=0.85 and 0.09, respectively). On contrary, Hashimoto’s disease was slightly more frequent in controls, but the difference was not significant (p=0.70).Conclusion: The present study demonstrates no significant association between hypothyroidism and BBD.