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Large genomic rearrangements (LGRs) affecting one or more exons of <i>BRCA1</i> and <i>BRCA2</i> constitute a significant part of the mutation spectrum of these genes. Since 2004, the National Institute of Oncology, Hungary, has been involved in screening for LGRs of breast or ovarian cancer families enrolled for genetic testing. LGRs were detected by multiplex ligation probe amplification method, or next-generation sequencing. Where it was possible, transcript-level characterization of LGRs was performed. Phenotype data were collected and analyzed too. Altogether 28 different types of LGRs in 51 probands were detected. Sixteen LGRs were novel. Forty-nine cases were deletions or duplications in <i>BRCA1</i> and two affected <i>BRCA2</i>. Rearrangements accounted for 10% of the <i>BRCA1</i> mutations. Three exon copy gains, two complex rearrangements, and 23 exon losses were characterized by exact breakpoint determinations. The inferred mechanisms for LGR formation were mainly end-joining repairs utilizing short direct homologies. Comparing phenotype features of the LGR-carriers to that of the non-LGR <i>BRCA1</i> mutation carriers, revealed no significant differences. Our study is the largest comprehensive report of LGRs of <i>BRCA1/2</i> in familial breast and ovarian cancer patients in the Middle and Eastern European region. Our data add novel insights to genetic interpretation associated to the LGRs.