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Introduction The medical field is very stressful. To reduce stress, healthcare workers may resort to different habits, including smoking and drinking. Objectives We aimed to assess the smoking and drinking habits of interns and fellows in Tunisian hospitals. Methods A cross-sectional study was conducted in April 2022 through online platforms. A pre-established questionnaire was sent to Tunisian medical interns and fellows, working in public hospitals, and collected sociodemographic and occupational data. The Fagerstörm test was used to evaluate nicotine dependence. Results Our population consisted of 182 Tunisian interns and fellows. Their mean age was 26.38±2.03 years. Females represented 71.4% of the total population. One hundred of them (54.95%) were fellows, out of which 18% specialized in surgery. Sixty-one per cent of these young doctors were single. Twenty-two individuals were smokers with male predominance (59.1%). Smoking was associated with age (p<0.001) and female sex (p=0.001). Fagerstörm test score’s mean was 4.09±2.52. High to very high nicotine dependency was found in 31.8% of cases. Thirty-five interns and fellows consumed alcohol and 51.4% of them were females. Alcohol use was associated with sex (p<0.001). Conclusions Despite knowing their hazard, young doctors still resort to drinking and smoking as a coping mechanism. The promotion of healthier coping mechanisms is essential. Disclosure of Interest None Declared