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Between April 2020 and November 2021, the Chinese Breast Cancer Society developed practice guideline on screening and early diagnosis of breast cancer in China, which was adapted from European Commission Initiative on Breast Cancer with GRADE approach. This practice guideline includes 50 recommendations and 5 expert consensus statements, with a scope of screening, early diagnosis, genetic testing on recurrence risk, and communication and training in the screening program. The formulation of recommendations considered best available evidence-based medicine, sense of worth and preferences of Chinese women, and cost and resource utilization. The implementation of recommended screening and diagnostic strategies need to consider the local contexts.