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Objective: We evaluated the treatment efficacy of clomiphene citrate (CC) in hypogonadal men. Methods: We retrospectively reviewed our patients with a diagnosis of hypogonadism who received CC treatment, and compared the pretreatment and post-treatment serum testosterone levels. Subjective patient improvements were recorded using the Androgen Deficiency in Aging Males questionnaire. Results: A total of 10 patients were included in our analysis. Mean serum testosterone level increase from 246 ± 76 ng/dL to 548 ± 281 ng/dL was noted after treatment (p < 0.01). Eight (80%) patients successfully reached a target serum testosterone level of > 400 ng/dL after treatment. Conclusion: CC is an effective alternative treatment for patients with hypogonadism.