Direct amidation of esters with nitroarenes
oleh: Chi Wai Cheung, Marten Leendert Ploeger, Xile Hu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-03-01 |
Deskripsi
Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.