Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice
oleh: Kayoko Nagata, Daichi Utsumi, Masamitsu N. Asaka, Ryota Maeda, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Yohei Yanagida, Yugo Kawai, Kei Sato, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Yasuhiro Yasutomi, Akihiro Imura, Akifumi Takaori-Kondo
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail also suppresses weight loss and prolongs survival of SARS-CoV-2 infected human ACE2 transgenic mice.