Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism

oleh: Mahya Mehrmohamadi, Lucas K. Mentch, Andrew G. Clark, Jason W. Locasale

Format: Article
Diterbitkan: Nature Portfolio 2016-12-01

Deskripsi

Altered DNA methylation is a feature of cancer and between-patient variability is prevalent. Here, the authors integrate data on thousands of human tumours, and find that expression levels of methionine metabolism genes are predictive of methylation features, and that the breakdown of this relationship is a negative prognostic marker.